Serotonin Transporter

5-HTT; SERT; SLC6A4

Serotonin Transporter

Related Products

Serotonin Transporters (SERTs) are integral membrane proteins that transport serotonin from synaptic spaces into presynaptic neurons. SERTs function by reuptaking serotonin in the synaptic cleft, effectively terminating the function of serotonin and halting neuronal transmission. Serotonin reuptake is a critical process to prevent overstimulation of nerves.

Serotonin transporter (SERT) regulates extracellular levels of serotonin (5-hydroxytryptamine, 5HT) in the brain by transporting 5HT into neurons and glial cells. The human SERT (hSERT) is the primary target for drugs used in the treatment of emotional disorders, including depression. hSERT belongs to the solute carrier 6 family that includes a bacterial leucine transporter (LeuT), for which a high resolution crystal structure has become available.

Serotonin Transporter Related Products (225)
Antibodies (3)

By Effects:	Controls (3) Ligand (1) Inhibitors (197) Agonist (1) Antagonists (2) Activators (2) Modulators (4)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-B0103AS

(E)-Fluvoxamine-d₄ maleate
(E)-Fluvoxamine-d₄ (maleate) is the deuterium labeled (E)-Fluvoxamine maleate[1].

HY-B0168S

Milnacipran-d₁₀ hydrochloride	Inhibitor
Milnacipran-d₁₀ (hydrochloride) is the deuterium labeled Milnacipran hydrochloride. Milnacipran hydrochloride is a serotonin-norepinephrine reuptake inhibitor (SNRI) used in the clinical treatment of fibromyalgia[1][2].

HY-B0492S

rel-Paroxetine-d₄-1 hydrochloride
(rac)-(trans)-Paroxetine-d₄ (hydrochloride) is the deuterium labeled (rac)-(trans)-Paroxetine hydrochloride[1].

HY-B0161S

Duloxetine-d₇	Inhibitor
Duloxetine-d₇ ((S)-Duloxetine-d₇) is the deuterium labeled Duloxetine. Duloxetine is a serotonin-norepinephrine reuptake inhibitor with a Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD)[1][2].

HY-101684A

Nitroxazepine hydrochloride	Inhibitor
Nitroxazepine hydrochloride is a tricyclic antidepressant (TCA) for the treatment of depression. Nitroxazepine acts as a serotonin-norepinephrine reuptake inhibitor.

HY-B0196S3

Venlafaxine-d₁₀	Inhibitor
Venlafaxine-d₁₀ (Wy 45030-d₁₀) is deuterium labeled Venlafaxine. Venlafaxine (Wy 45030) is an orally active, potent serotonin (5-HT)/norepinephrine (NE) reuptake dual inhibitor. Venlafaxine is an antidepressant.

HY-135556A

Norfluoxetine oxalate
Norfluoxetine oxalate is an active metabolite of Fluoxetine (HY-B0102). Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) class used for antidepressant research.

HY-B0196S2

Venlafaxine-d₄	Inhibitor
Venlafaxine-d₄ (Wy 45030-d₄) is deuterium labeled Venlafaxine. Venlafaxine (Wy 45030) is an orally active, potent serotonin (5-HT)/norepinephrine (NE) reuptake dual inhibitor. Venlafaxine is an antidepressant.

HY-W587542

(1S,4S)-N-Desmethyl Sertraline hydrochloride	Inhibitor
(1S,4S)-N-Desmethyl Sertraline (hydrochloride) is a metabolite of Sertraline. (1S,4S)-N-Desmethyl Sertraline (hydrochloride) is a selective serotonin uptake blocker with antidepressant properties.

HY-B1490AS

Imipramine-d₆	Inhibitor
Imipramine-d₆ is the deuterium labeled Imipramine hydrochloride. Imipramine is an orally active tertiary amine tricyclic antidepressant. Imipramine is a Fascin1 inhibitor with antitumor activities. Imipramine also inhibits serotonin transporter with an IC50 value of 32 nM. Imipramine stimulates U-87MG glioma cells autophagy and induces HL-60 cell apoptosis. Imipramine shows neuroprotective and immunomodulatory effects[1][2][3][4][5][6].

HY-B0168AR

Milnacipran (hydrochloride) (Standard)	Inhibitor
Milnacipran (hydrochloride) (Standard) is the analytical standard of Milnacipran (hydrochloride). This product is intended for research and analytical applications. Milnacipran is a serotonin-norepinephrine reuptake inhibitor (SNRI) used for fibromyalgia.

HY-18332

Amitifadine	Inhibitor
Amitifadine (DOV-21947) is an antidepressant drug candidate that functions as a triple reuptake inhibitor, targeting the reuptake of serotonin, norepinephrine, and dopamine, and has been shown to decrease binge drinking and alleviate negative emotions in animal models.

HY-133171A

(S)-Norfluoxetine	Inhibitor
(S)-Norfluoxetine, a S enantiomer of Norfluoxetine (HY-135556), is a selective serotonin reuptake inhibitor. (S)-Norfluoxetine can increase allopregnanolone levels and reduce aggression in socially isolated mice.

HY-B0102S

Fluoxetine-d₆	Inhibitor
Fluoxetine-d₆ (LY-110140 (free base)-d₆) is deuterium labeled Fluoxetine. Fluoxetine (LY-110140 free base) is a selective serotonin reuptake inhibitor (SSRI) class used for antidepressant research.

HY-107370S

Atomoxetine-d₇	Inhibitor
Atomoxetine-d₇ (Tomoxetine-d₇) is deuterium labeled Atomoxetine. Atomoxetine (Tomoxetine) is a selective noradrenaline reuptake inhibitor with K_i values of 5, 77 and 1451 nM for norepinephrine (NE), serotonin (5-HT) and dopamine (DA) transporters, respectively. Atomoxetine (Tomoxetine) increases of DA_EX and NE_EX in the PFC and enhances catecholaminergic neurotransmission. Atomoxetine (Tomoxetine) is a potent Na⁺ channels (VGSCs) blocker. Atomoxetine (Tomoxetine) can be used for attention-deficit hyperactivity disorder (ADHD) research.

HY-B0103AS2

Fluvoxamine-¹³C, d₃ maleate	Inhibitor
Fluvoxamine-¹³C, d₃ maleate is ¹³C and deuterated labeled Fluvoxamine maleate (HY-B0103A). Fluvoxamine maleate (DU-23000 maleate) is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor.

HY-W710914A

rel-HDMP 28 hydrochloride
rel-HDMP 28 hydrochloride (Compound 2g) is a methylphenidate analogue that binds selectively to SERT (K_i = 105 nM)_[1].

HY-B1490AS3

Imipramine-d₄-1	Inhibitor
Imipramine-d4-1 is the deuterium labeled Imipramine (HY-W010179). Imipramine is an orally active tertiary amine tricyclic antidepressant. Imipramine is a Fascin1 inhibitor with antitumor activities. Imipramine also inhibits serotonin transporter with an IC₅₀ value of 32 nM. Imipramine stimulates U-87MG glioma cells autophagy and induces HL-60 cell apoptosis. Imipramine shows neuroprotective and immunomodulatory effects.

HY-W158945

3-Chloroamphetamine hydrochloride	Activator
3-Chloroamphetamine hydrochloride is a derivative of Amphetamine that acts as a central nervous system stimulant by releasing serotonin and dopamine.

HY-126380

Nardosinonediol	Inhibitor
Nardosinonediol (Tetrahydronardosinon) is a serotonin transporter (SERT) inhibitor.

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Serotonin Transporter

Serotonin Transporter

Serotonin Transporter Related Products (225)

Antibodies (3)

Serotonin Transporter Related Products (225):